Pharmacy COC
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1, Which of the following processes proceeds in the second phase of biotransformation?
A. Acetylation B. Reduction
C. Oxidation D. Hydrolysis
3, Indicate the drug which increases absorption of iron from intestine:
a) Cyanocobalamin
b) Folic acid
c) Ascorbic acid
d) Erythropoetin
4, The body's least desirable source of energy are?.
A, Carbohydrates B. Proteins
C.Fats D.Vitamins
5, Pharmacodynamics involves the study of following EXCEPT:
A. Biological and therapeutic effects of drugs
B. Absorption and distribution of drugs
C. Mechanisms of drug action
D. Drug interactions
6, A patient prescribed to take antifungal drug for his topical nail infection for 3 months duration. The absorption of this drug is increase by fatty food. Which is the drug?
A.Ketoconazole C. Itraconazole
B. grisofulvine D. terbinafine
7,. Which of the following NSAIDs is a pyrazolone derivative?
A. Ibuprofen
A. Acetylation B. Reduction
C. Oxidation D. Hydrolysis
3, Indicate the drug which increases absorption of iron from intestine:
a) Cyanocobalamin
b) Folic acid
c) Ascorbic acid
d) Erythropoetin
4, The body's least desirable source of energy are?.
A, Carbohydrates B. Proteins
C.Fats D.Vitamins
5, Pharmacodynamics involves the study of following EXCEPT:
A. Biological and therapeutic effects of drugs
B. Absorption and distribution of drugs
C. Mechanisms of drug action
D. Drug interactions
6, A patient prescribed to take antifungal drug for his topical nail infection for 3 months duration. The absorption of this drug is increase by fatty food. Which is the drug?
A.Ketoconazole C. Itraconazole
B. grisofulvine D. terbinafine
7,. Which of the following NSAIDs is a pyrazolone derivative?
A. Ibuprofen
B. Indomethacin
C. Metamizole (Analgin)
D. Diclofenac
8, Stimulation of liver microsomal enzymes can:
A) Require the dose increase of some drugs
B) Require the dose decrease of some drugs
C) Prolong the duration of the action of a drug
D) Intensify the unwanted reaction of a drug
9, The drug of choice for wrinkle encephalopathy?
A. Revoflavin C. Phyridoxin
B. Thiamin D. Niacin
10, Pick out the answer which is the most appropriate to the term “receptor”
A) All types of ion channels modulated by a drug
B) Enzymes of oxidizing-reducing reactions activated by a drug
C) Active macromolecular components of a cell or an organism which a drug molecule has to combine with in order to elicit its specific effect
D) Carriers activated by a drug
11, A patient who has PUD does not get relief by Paracetamol from his pain.
Which of the following drug should be prescribed to him?
A. Diclofenac C. Meloxicame
B. Indomethacin D. Prednisolone
12, A patient takes antacid and doxycycline. Which of the following food should not be used?
A. Fruit C. Orange
B. Banana D. Dairy products
13, A 65 patient comes to your hospital for medical treatment. The physician diagnosis GERD, which drug should be prescribed?
A. Pantoprazole C. Ranitidine
B. Sodium bicarbonate D. Cimetidine
14, Which drug causes hypokalemia?
A. Spironolactone C. Thiazide diuretics
B. Triamterene D. Digoxin
15, A fresh pharmacist who is doing at the dispensary at the first time gets the prescription that is on read the first letter (D) and the last letter (L). What he does?
A. Dispense Danavil
B. Return to the prescriber
C. Recommend to other senior pharmacy
D. Reject
16, A quality control department wants to inspect community pharmacies randomly beyond the inspection program. What types of inspection is done?
A. Programmed inspection
B. Sudden inspection
C. Scheduled inspection
D. Annual inspection
17, . Conjugation of a drug includes the following EXCEPT:
A) Glucoronidation
B) Sulfate formation
C) Hydrolysis
D) Methylation
18, Which recording card should be kept in the drug shelf
A. Stock card C. Ledger card
B. Bincard D.RRF
19, The volume of distribution (Vd) relates:
A) Single to a daily dose of an administrated drug
B) An administrated dose to a body weight
C) An uncharged drug reaching the systemic circulation
D) The amount of a drug in the body to the concentration of a drug in plasma
20, A pharmacist wants to keep drugs on the pallet. What is the appropriate storage of pallet?
A. at least 20cm away from the wall
B. at least 20cm away from the floor
C. at least 30cm away from the wall
D. at least 1meter from the floor
21, A pharmacist wants to prepare two incompatible active ingredients in one tablet. Which of the following methods are used for this preparation?
A. Press coating C. Enteric coating
B. Sugar coating D. Sustained release preparation
22, A pharmacist working in the health center wants to send report and requisition form (RRF) report to Woreda health office. Which is the date of submission to this report?
A. 1-3days C. 1-5days
B. 1-10days D. 1-15days
23, What does “affinity” mean?
A) A measure of how tightly a drug binds to plasma proteins
B) A measure of how tightly a drug binds to a receptor
C) A measure of inhibiting potency of a drug
D) A measure of bioavailability of a drug
24, The pharmacist wants to procure the most costy and most effective drug, before procure what the pharmacist do?
A. Cost effectiveness analysis
B. Cost benefit analysis
C. Cost utility analysis
D. ABC analysis
25, Conjugation is:
A) Process of drug reduction by special enzymes
B) Process of drug oxidation by special oxidases
C) Coupling of a drug with an endogenous substrate
D) Solubilization in lipids
26, A physician prescribes enteric coated tablet for the treatment of constipation. What is the drug?
A. Amoxicillin C. Bisacodyle
B. Cloxacillin D. Gentamycine
27, What is the reason of complicated penetration of some drugs through brain-blood barrier?
A) High lipid solubility of a drug
B) Meningitis
C) Absence of pores in the brain capillary endothelium
D) High endocytosis degree in a brain capillary
28, Which route of drug administration is most affected by first pass effect?
A. Oral C. Rectal
B. Vaginal D. SC
29, Which drug is best for the treatment emergency asthma?
A. Beclomethasone C. Fluticasone
B. Albuterol D. Prednisolone
30, Metabolic transformation (phase 1) is:
A) Acetylation and methylation of substances
B) Transformation of substances due to oxidation, reduction or hydrolysis
C) Glucuronide formation
D) Binding to plasma proteins
31, A patient comes to your hospital for medical checkup for his hypertension and gout who was in hydrochlorothiazide and prednisolone. Vital sign shows that BP 140/86 mmhg normal uricacid level and currently the physician diagnosis shows Cushing’s syndrome, which of the following drugs should not be added to this patient?
A. Enalaprile B. Furosemide
C. Prednisolone D. Propranolol
32, Beta-blocking drugs-induced chronically lower blood pressure may be associated with theirs effects on:
A. The heart
B. The blood vessels
C. The renin-angiotensin system
D. All of the above
33, A physician order diazepam 5mg po PRN. From the order which affects the treatment most?
A. Dose B. Route C. Frequency D. Drug
34,. Characteristics of beta-blocking agents include all of the following EXCEPT:
A. They occupy beta receptors and competitively reduce receptor occupancy by catecholamines or other beta agonists
B. They do not cause hypotension in individuals with normal blood pressure
C. They induce depression and depleted stores of catecholamines
D. They can cause blockade in the atrioventricular node
35, You were working as store man pharmacist and wants to procure NG tube due to stock. As a pharmacist what should be consider first.
A. Thickness B. Cost
C. Size D. Length
36, For the calculation of the volume of distribution (Vd) one must take into account:
A) Concentration of a substance in plasma
B) Concentration of substance in urine
C) Therapeutical width of drug action
D) A daily dose of drug
37, A nurse wants reusable medical supply for her routine activities. If she wants to request this supply to pharmacy which supply may be procured?
A. Disposable syringe
B. Absorbable cat gut
C. Glass syringe
D. Plaster
38, Which of the following statements concerning vitamin B12 (cyanocobalamin) functions are true:
A) Active functional form is pyridoxal phosphate, which is an essential coenzyme for transamination and decarboxylation of amino acids in more than 50 different enzyme systems
B) Essential constituent of coenzyme A, the important coenzyme for acyl transfer in the TCA cycle and de novo fatty acid synthesis
C) Coenzyme for numerous metabolic reaction, including transformation of methylamlonyl CoA to succinyl CoA in the metabolism of propionate; DNA synthesis (acts in concert with folic acid); transmethylation e.g. methionine synthesis from homocysteine
D) An extremely important antioxidant, which protects cell membrane lipids from peroxidation by breaking the chain reaction of free radical formation to which polyunsaturated fatty acids are particularly vulnerable
39, Which is referred first and best method to find information
A. Textbook B. clinical studies
C. indexing D. abstracting service
40, Pick out the right statement:
A) Microsomal oxidation always results in inactivation of a compound
B) Microsomal oxidation results in a decrease of compound toxicity
C) Microsomal oxidation results in an increase of ionization and water solubility of a drug
D) Microsomal oxidation results in an increase of lipid solubility of a drug thus its excretion from the organism is facilitated
41, Mr. Abebe takes phenelezin for his depression. Which of the following food is not used together?
A. Cheese B. Coffee
C. Tea D. Banana
41, Indicate an alfa receptor antagonist, which is an efficacious drug in the treatment of mild to moderate systemic
hypertension:
A) Phentolamine
B) Tolazoline
C) Ergotamine
D) Prazosin
42, A quality control company wants to inspect the manufacturing quality of the drug manufacturer. What the inspector inspects?
A. Good laboratory practice
B. Good dispensing practice
C. Good manufacturing practice
D. Good procurement practice
43, A physician prescribes AZT+D4T+NVP? Which drug interacts each other? (AZT with D4T) A physician wants to prescribe for a 37 year patient prophylaxis drugs to opportunistic infections for HIV/AIDS patients. Which of the following drug is prescribed.
A. Zidovudin B. Limovudin
C. ANS=cotrimoxazole 960mg QD D. None
44, When to give ASA for ischemic heart disease patients
A. Within 24 hours of disease onset
B. Within 48 hours of disease onset
C. Within 72 hours of disease onset
D. Within 3 hours of disease onset
45, Which of the following is true when phenobarbital and warfarin is used together?
A. Increase warfarin toxicity
B. Decrease phenobarbital totoxicit
C. Decrease warfarin toxicity, decrease bleeding
D. Increase phenobarbital toxicity
46, Biological barriers include all except:
A. Renal tubules
B. Cell membranes
C. Capillary walls
D. Placenta
47, For which of pharmaceuticals FEFO is strictly used?
A. Contraceptive B. Vaccines
C. Antibiotics D. Medical equipments
48, . Beta-blocking agents have all of the following effects except:
A) Increase plasma concentrations of HDL and decrease of VLDL
B) Bronchoconstriction
C) Decrease of aqueous humor prodaction
D) “membrane-stabilizing” action
49 , You are working in the drug manufacturing company and prepares drugs of having trace metals and air sensitive formulation. Which of the following excipient(s) are used to formulate this drugs?
A. Chelating agent and preservative
B. Chelating agent and anti-oxidant
C. Chelating agent
D. Preservative
50, . Pharmacodynamics involves the following?
A) Information about main mechanisms of drug absorption
B) Information about unwanted effects
C) Information about biological barriers
D) Information about excretion of a drug from the organism
C. Metamizole (Analgin)
D. Diclofenac
8, Stimulation of liver microsomal enzymes can:
A) Require the dose increase of some drugs
B) Require the dose decrease of some drugs
C) Prolong the duration of the action of a drug
D) Intensify the unwanted reaction of a drug
9, The drug of choice for wrinkle encephalopathy?
A. Revoflavin C. Phyridoxin
B. Thiamin D. Niacin
10, Pick out the answer which is the most appropriate to the term “receptor”
A) All types of ion channels modulated by a drug
B) Enzymes of oxidizing-reducing reactions activated by a drug
C) Active macromolecular components of a cell or an organism which a drug molecule has to combine with in order to elicit its specific effect
D) Carriers activated by a drug
11, A patient who has PUD does not get relief by Paracetamol from his pain.
Which of the following drug should be prescribed to him?
A. Diclofenac C. Meloxicame
B. Indomethacin D. Prednisolone
12, A patient takes antacid and doxycycline. Which of the following food should not be used?
A. Fruit C. Orange
B. Banana D. Dairy products
13, A 65 patient comes to your hospital for medical treatment. The physician diagnosis GERD, which drug should be prescribed?
A. Pantoprazole C. Ranitidine
B. Sodium bicarbonate D. Cimetidine
14, Which drug causes hypokalemia?
A. Spironolactone C. Thiazide diuretics
B. Triamterene D. Digoxin
15, A fresh pharmacist who is doing at the dispensary at the first time gets the prescription that is on read the first letter (D) and the last letter (L). What he does?
A. Dispense Danavil
B. Return to the prescriber
C. Recommend to other senior pharmacy
D. Reject
16, A quality control department wants to inspect community pharmacies randomly beyond the inspection program. What types of inspection is done?
A. Programmed inspection
B. Sudden inspection
C. Scheduled inspection
D. Annual inspection
17, . Conjugation of a drug includes the following EXCEPT:
A) Glucoronidation
B) Sulfate formation
C) Hydrolysis
D) Methylation
18, Which recording card should be kept in the drug shelf
A. Stock card C. Ledger card
B. Bincard D.RRF
19, The volume of distribution (Vd) relates:
A) Single to a daily dose of an administrated drug
B) An administrated dose to a body weight
C) An uncharged drug reaching the systemic circulation
D) The amount of a drug in the body to the concentration of a drug in plasma
20, A pharmacist wants to keep drugs on the pallet. What is the appropriate storage of pallet?
A. at least 20cm away from the wall
B. at least 20cm away from the floor
C. at least 30cm away from the wall
D. at least 1meter from the floor
21, A pharmacist wants to prepare two incompatible active ingredients in one tablet. Which of the following methods are used for this preparation?
A. Press coating C. Enteric coating
B. Sugar coating D. Sustained release preparation
22, A pharmacist working in the health center wants to send report and requisition form (RRF) report to Woreda health office. Which is the date of submission to this report?
A. 1-3days C. 1-5days
B. 1-10days D. 1-15days
23, What does “affinity” mean?
A) A measure of how tightly a drug binds to plasma proteins
B) A measure of how tightly a drug binds to a receptor
C) A measure of inhibiting potency of a drug
D) A measure of bioavailability of a drug
24, The pharmacist wants to procure the most costy and most effective drug, before procure what the pharmacist do?
A. Cost effectiveness analysis
B. Cost benefit analysis
C. Cost utility analysis
D. ABC analysis
25, Conjugation is:
A) Process of drug reduction by special enzymes
B) Process of drug oxidation by special oxidases
C) Coupling of a drug with an endogenous substrate
D) Solubilization in lipids
26, A physician prescribes enteric coated tablet for the treatment of constipation. What is the drug?
A. Amoxicillin C. Bisacodyle
B. Cloxacillin D. Gentamycine
27, What is the reason of complicated penetration of some drugs through brain-blood barrier?
A) High lipid solubility of a drug
B) Meningitis
C) Absence of pores in the brain capillary endothelium
D) High endocytosis degree in a brain capillary
28, Which route of drug administration is most affected by first pass effect?
A. Oral C. Rectal
B. Vaginal D. SC
29, Which drug is best for the treatment emergency asthma?
A. Beclomethasone C. Fluticasone
B. Albuterol D. Prednisolone
30, Metabolic transformation (phase 1) is:
A) Acetylation and methylation of substances
B) Transformation of substances due to oxidation, reduction or hydrolysis
C) Glucuronide formation
D) Binding to plasma proteins
31, A patient comes to your hospital for medical checkup for his hypertension and gout who was in hydrochlorothiazide and prednisolone. Vital sign shows that BP 140/86 mmhg normal uricacid level and currently the physician diagnosis shows Cushing’s syndrome, which of the following drugs should not be added to this patient?
A. Enalaprile B. Furosemide
C. Prednisolone D. Propranolol
32, Beta-blocking drugs-induced chronically lower blood pressure may be associated with theirs effects on:
A. The heart
B. The blood vessels
C. The renin-angiotensin system
D. All of the above
33, A physician order diazepam 5mg po PRN. From the order which affects the treatment most?
A. Dose B. Route C. Frequency D. Drug
34,. Characteristics of beta-blocking agents include all of the following EXCEPT:
A. They occupy beta receptors and competitively reduce receptor occupancy by catecholamines or other beta agonists
B. They do not cause hypotension in individuals with normal blood pressure
C. They induce depression and depleted stores of catecholamines
D. They can cause blockade in the atrioventricular node
35, You were working as store man pharmacist and wants to procure NG tube due to stock. As a pharmacist what should be consider first.
A. Thickness B. Cost
C. Size D. Length
36, For the calculation of the volume of distribution (Vd) one must take into account:
A) Concentration of a substance in plasma
B) Concentration of substance in urine
C) Therapeutical width of drug action
D) A daily dose of drug
37, A nurse wants reusable medical supply for her routine activities. If she wants to request this supply to pharmacy which supply may be procured?
A. Disposable syringe
B. Absorbable cat gut
C. Glass syringe
D. Plaster
38, Which of the following statements concerning vitamin B12 (cyanocobalamin) functions are true:
A) Active functional form is pyridoxal phosphate, which is an essential coenzyme for transamination and decarboxylation of amino acids in more than 50 different enzyme systems
B) Essential constituent of coenzyme A, the important coenzyme for acyl transfer in the TCA cycle and de novo fatty acid synthesis
C) Coenzyme for numerous metabolic reaction, including transformation of methylamlonyl CoA to succinyl CoA in the metabolism of propionate; DNA synthesis (acts in concert with folic acid); transmethylation e.g. methionine synthesis from homocysteine
D) An extremely important antioxidant, which protects cell membrane lipids from peroxidation by breaking the chain reaction of free radical formation to which polyunsaturated fatty acids are particularly vulnerable
39, Which is referred first and best method to find information
A. Textbook B. clinical studies
C. indexing D. abstracting service
40, Pick out the right statement:
A) Microsomal oxidation always results in inactivation of a compound
B) Microsomal oxidation results in a decrease of compound toxicity
C) Microsomal oxidation results in an increase of ionization and water solubility of a drug
D) Microsomal oxidation results in an increase of lipid solubility of a drug thus its excretion from the organism is facilitated
41, Mr. Abebe takes phenelezin for his depression. Which of the following food is not used together?
A. Cheese B. Coffee
C. Tea D. Banana
41, Indicate an alfa receptor antagonist, which is an efficacious drug in the treatment of mild to moderate systemic
hypertension:
A) Phentolamine
B) Tolazoline
C) Ergotamine
D) Prazosin
42, A quality control company wants to inspect the manufacturing quality of the drug manufacturer. What the inspector inspects?
A. Good laboratory practice
B. Good dispensing practice
C. Good manufacturing practice
D. Good procurement practice
43, A physician prescribes AZT+D4T+NVP? Which drug interacts each other? (AZT with D4T) A physician wants to prescribe for a 37 year patient prophylaxis drugs to opportunistic infections for HIV/AIDS patients. Which of the following drug is prescribed.
A. Zidovudin B. Limovudin
C. ANS=cotrimoxazole 960mg QD D. None
44, When to give ASA for ischemic heart disease patients
A. Within 24 hours of disease onset
B. Within 48 hours of disease onset
C. Within 72 hours of disease onset
D. Within 3 hours of disease onset
45, Which of the following is true when phenobarbital and warfarin is used together?
A. Increase warfarin toxicity
B. Decrease phenobarbital totoxicit
C. Decrease warfarin toxicity, decrease bleeding
D. Increase phenobarbital toxicity
46, Biological barriers include all except:
A. Renal tubules
B. Cell membranes
C. Capillary walls
D. Placenta
47, For which of pharmaceuticals FEFO is strictly used?
A. Contraceptive B. Vaccines
C. Antibiotics D. Medical equipments
48, . Beta-blocking agents have all of the following effects except:
A) Increase plasma concentrations of HDL and decrease of VLDL
B) Bronchoconstriction
C) Decrease of aqueous humor prodaction
D) “membrane-stabilizing” action
49 , You are working in the drug manufacturing company and prepares drugs of having trace metals and air sensitive formulation. Which of the following excipient(s) are used to formulate this drugs?
A. Chelating agent and preservative
B. Chelating agent and anti-oxidant
C. Chelating agent
D. Preservative
50, . Pharmacodynamics involves the following?
A) Information about main mechanisms of drug absorption
B) Information about unwanted effects
C) Information about biological barriers
D) Information about excretion of a drug from the organism
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